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anglemania is a new approach to the integration of scRNA-seq (and, potentially, others sc-omics) from similar biological entities. The novelty, as well as the cornerstone, of the proposed approach, is to use the conservation of angles between gene pairs across an assembly of datasets to be integrated. anglemania extracts genes from gene pairs that exhibit invariant and biologically meaningful relationships across different experiments. Those genes can subsequently be used as the basis for integration algorithms such as [Seurat CCA integration], [SCVI] and others. Checkout our [website].
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You can install anglemania from Bioconductor using the following commands:
# Install BiocManager if you haven't already
if (!requireNamespace("BiocManager", quietly = TRUE))
install.packages("BiocManager")
# Install anglemania
BiocManager::install("anglemania")For the development version from GitHub:
# Install devtools if you haven't already
if (!requireNamespace("devtools", quietly = TRUE))
install.packages("devtools")
# Install from GitHub
devtools::install_github("BIMSBbioinfo/anglemania/")Comprehensive documentation is available on our [anglemania website] Or visit the Bioconductor package page.
If you encounter issues or have questions:
- Submit issues on GitHub Issues.
Artistic License/GPL
If you use anglemania in your research, please cite:
Aaron Kollotzek, Vedran Franke, Artem Baranovskii, Altuna Akalin(2024). *anglemania: Feature Extraction for scRNA-seq Dataset Integration. R package version 0.99.0