diff --git a/pkg/collector/python/init_windows.go b/pkg/collector/python/init_windows.go
index 04d18175df1f7..47fed549c783f 100644
--- a/pkg/collector/python/init_windows.go
+++ b/pkg/collector/python/init_windows.go
@@ -9,8 +9,10 @@ package python
 
 import (
 	"os"
+	"path/filepath"
 
 	pkgconfigsetup "github.com/DataDog/datadog-agent/pkg/config/setup"
+	"github.com/DataDog/datadog-agent/pkg/util/winutil"
 )
 
 // Any platform-specific initialization belongs here.
@@ -21,5 +23,25 @@ func initializePlatform() error {
 		os.Unsetenv("PYTHONPATH")
 	}
 
+	// get program data directory and set PYTHONPYCACHEPREFIX
+	pd, err := winutil.GetProgramDataDir()
+	if err != nil {
+		return err
+	}
+	pycache := filepath.Join(pd, "python-cache")
+
+	// check if path exists
+	if _, err := os.Stat(pycache); os.IsNotExist(err) {
+		// create the directory
+		if err := os.MkdirAll(pycache, 0755); err != nil {
+			return err
+		}
+	} else if err != nil {
+		return err
+	}
+	// TODO check if we have access to the directory ?
+
+	os.Setenv("PYTHONPYCACHEPREFIX", pycache)
+
 	return nil
 }
diff --git a/tools/windows/DatadogAgentInstaller/CustomActions/ConfigureUserCustomActions.cs b/tools/windows/DatadogAgentInstaller/CustomActions/ConfigureUserCustomActions.cs
index 7b3479f2beb5d..7a5b6e03a93c3 100644
--- a/tools/windows/DatadogAgentInstaller/CustomActions/ConfigureUserCustomActions.cs
+++ b/tools/windows/DatadogAgentInstaller/CustomActions/ConfigureUserCustomActions.cs
@@ -632,9 +632,8 @@ private List<string> PathsWithAgentAccess()
                 Path.Combine(configRoot, "system-probe.yaml"),
                 Path.Combine(configRoot, "auth_token"),
                 Path.Combine(configRoot, "install_info"),
-                Path.Combine(_session.Property("PROJECTLOCATION"), "embedded2"),
-                Path.Combine(_session.Property("PROJECTLOCATION"), "embedded3"),
-            }; ;
+                Path.Combine(configRoot, "python-cache"),
+            };
         }
 
         /// <summary>
diff --git a/tools/windows/DatadogAgentInstaller/WixSetup/Datadog Agent/AgentInstaller.cs b/tools/windows/DatadogAgentInstaller/WixSetup/Datadog Agent/AgentInstaller.cs
index f7aaaf44ca494..46ab4dc2d0b88 100644
--- a/tools/windows/DatadogAgentInstaller/WixSetup/Datadog Agent/AgentInstaller.cs	
+++ b/tools/windows/DatadogAgentInstaller/WixSetup/Datadog Agent/AgentInstaller.cs	
@@ -552,6 +552,7 @@ private Dir CreateAppDataFolder()
             var appData = new Dir(new Id("APPLICATIONDATADIRECTORY"), "Datadog",
                 new DirFiles($@"{EtcSource}\*.yaml.example"),
                 new Dir("checks.d"),
+                new Dir("python-cache"),
                 new Dir("run"),
                 new Dir("logs"),
                 new Dir(new Id("EXAMPLECONFSLOCATION"), "conf.d",