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NCIT Release v2024-05-07

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@matentzn matentzn released this 07 May 18:07
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Synonyms added: 18744
Term New Synonym Predicate
Steroid Resistant Acute Graft Versus Host Disease (NCIT:C168582) Steroid Refractory Acute Graft Versus Host Disease oio:hasExactSynonym
Steroid Resistant Acute Graft Versus Host Disease (NCIT:C168582) Steroid Refractory Acute GVHD oio:hasExactSynonym
Steroid Resistant Acute Graft Versus Host Disease (NCIT:C168582) Steroid Resistant Acute GVHD oio:hasExactSynonym
Neuroendocrine Tumor G1 (NCIT:C203250) NET G1 oio:hasExactSynonym
Neuroendocrine Tumor G1 (NCIT:C203250) Neuroendocrine Tumor G1 oio:hasExactSynonym
Neuroendocrine Tumor G1 (NCIT:C203250) Neuroendocrine Tumor Grade 1 oio:hasExactSynonym

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Mappings added: 8685
Subject Predicate Object
Steroid Resistant Acute Graft Versus Host Disease (NCIT:C168582) subClassOf (rdfs:subClassOf) Steroid Refractory Graft Versus Host Disease (NCIT:C147114)
Recurrent Anaplastic Astrocytoma (NCIT:C136517) subClassOf (rdfs:subClassOf) Recurrent Astrocytic Tumor (NCIT:C203274)
Recurrent Anaplastic Astrocytoma (NCIT:C136517) subClassOf (rdfs:subClassOf) Recurrent Diffuse Glioma (NCIT:C203285)
Neuroendocrine Tumor G1 (NCIT:C203250) subClassOf (rdfs:subClassOf) Neuroendocrine Tumor (NCIT:C188218)
Locally Advanced Unresectable Digestive System Adenocarcinoma (NCIT:C202500) subClassOf (rdfs:subClassOf) Unresectable Digestive System Adenocarcinoma (NCIT:C129654)
Locally Advanced Unresectable Digestive System Adenocarcinoma (NCIT:C202500) subClassOf (rdfs:subClassOf) Locally Advanced Digestive System Carcinoma (NCIT:C153358)
Locally Advanced Unresectable Digestive System Adenocarcinoma (NCIT:C202500) subClassOf (rdfs:subClassOf) Locally Advanced Unresectable Carcinoma (NCIT:C155698)
Locally Advanced Unresectable Digestive System Adenocarcinoma (NCIT:C202500) subClassOf (rdfs:subClassOf) Locally Advanced Adenocarcinoma (NCIT:C168978)
EE99 R1-VAC (NCIT:C203577) subClassOf (rdfs:subClassOf) Treatment Arm for EURO-E.W.I.N.G.99 Combination Chemotherapy with or without Peripheral Stem Cell Transplantation, Radiation Therapy, and/or Surgery in Treating Patients with Ewing's Sarcoma (NCIT:C203561)
Sinonasal Angiosarcoma (NCIT:C173125) subClassOf (rdfs:subClassOf) Head and Neck Angiosarcoma (NCIT:C202656)
CDISC SDTM Category of Tobacco Products Terminology (NCIT:C204434) subClassOf (rdfs:subClassOf) Unused Subset Concept (NCIT:C103175)

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Classes added: 7906
Term
Neuroendocrine Tumor G1 (NCIT:C203250)
Neuroendocrine Tumor G1 (NCIT:C203250)
Locally Advanced Unresectable Digestive System Adenocarcinoma (NCIT:C202500)
Locally Advanced Unresectable Digestive System Adenocarcinoma (NCIT:C202500)
EE99 R1-VAC (NCIT:C203577)
EE99 R1-VAC (NCIT:C203577)
CDISC SDTM Category of Tobacco Products Terminology (NCIT:C204434)
CDISC SDTM Category of Tobacco Products Terminology (NCIT:C204434)
Vixicovtogene Oboplasmid (NCIT:C203254)
Vixicovtogene Oboplasmid (NCIT:C203254)
Head and Neck Teratoma (NCIT:C202980)
Head and Neck Teratoma (NCIT:C202980)

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Text definitions added: 3811
Term New Text Definition
Neuroendocrine Tumor G1 (NCIT:C203250) A well-differentiated, low-grade epithelial neoplasm with neuroendocrine differentiation. It arises from multiple sites, including the digestive system, lung, and head and neck.
Locally Advanced Unresectable Digestive System Adenocarcinoma (NCIT:C202500) Digestive system adenocarcinoma that has spread from its original site of growth to nearby tissues or lymph nodes and is not amenable to surgical resection.
EE99 R1-VAC (NCIT:C203577) Patients randomized with the following course sequence: 1) Group 1: Vincristine, dactinomycin and cyclophosphamide (VAC) (Dirksen U, et al. J Clin Oncol. 2019 Dec 1;37(34):3192-3202. Le Deley MC, et al. J Clin Oncol. 2014 Aug 10;32(23):2440-8.)
CDISC SDTM Category of Tobacco Products Terminology (NCIT:C204434) Terminology associated with the Category of Tobacco Products codelist of the Clinical Data Interchange Standards Consortium (CDISC) Study Data Tabulation Model (SDTM).
Head and Neck Teratoma (NCIT:C202980) An exceptionally rare mature or immature teratoma that arises from the head and neck region.
Subungual Space (NCIT:C204886) The area underneath a fingernail or toenail.
Peribulbar Route of Administration (NCIT:C65041) Administration of medication under the globe of the eye.
Familial Hemophagocytic Lymphohistiocytosis Type 2 (NCIT:C203462) Familial hemophagocytic lymphohistiocytosis caused by biallelic mutations in the PRF1 gene.
Engineered Interferon Alpha-2b Prodrug JZP898 (NCIT:C202905) An engineered, prodrug form of the human cytokine interferon alpha-2b (IFN-alpha-2b), composed of IFN-alpha-2b linked to a high affinity blockade element via a tumor protease-sensitive linker, and a half-life extension domain, with potential immunomodulatory and antineoplastic activities. Upon administration of engineered IFN-alpha-2b prodrug JZP898, IFN-alpha-2b is bound to the blockade element and pharmacologically inactive. Upon proteolytic cleavage in the tumor microenvironment (TME), active IFN-alpha-2b is released. IFN-alpha-2b binds to specific IFN cell-surface receptors. This activates IFN-mediated signal transduction pathways and induces the transcription and translation of genes with interferon-stimulated response elements (ISREs); the protein products mediate immunomodulating and antiproliferative effects. The selective activation in the TME enhances the IFN-alpha-2b-mediated immune responses against tumor cells while sparing the unwanted effects of systemic, peripheral immune activation. The inclusion of the half-life extension domain prolongs the agent's exposure in the tumor.

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Text definitions changed: 1201
Term Old Text Definition New Text Definition
Dexamethasone/Lenolidomide/Panobinostat Regimen (NCIT:C181602) A chemotherapy regimen consisting of dexamethasone, lenolidomide and panobinostat that can be used for the treatment of relapsed or refractory plasma cell (multiple) myeloma. A regimen consisting of dexamethasone, lenolidomide and panobinostat that can be used for the treatment of relapsed or refractory plasma cell (multiple) myeloma.
Reduced-dose FCR Regimen (NCIT:C181206) A chemoimmunotherapy regimen consisting of reduced-dose fludarabine, cyclophosphamide and rituximab that can be used for the treatment of chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL). A regimen consisting of reduced-dose fludarabine, cyclophosphamide and rituximab that can be used for the treatment of chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL).
Thermography (NCIT:C17194) A diagnostic technique using a thermograph to record the heat produced by different parts of the bod. It can be used to study blood flow and to detect tumors. A diagnostic technique using a thermograph to record the heat produced by different parts of the body. It can be used to study blood flow and to detect tumors.
OFF Regimen (NCIT:C114101) A chemotherapy regimen that includes leucovorin, 5-fluorouracil and oxaliplatin, which may be used in the treatment of pancreatic cancer. A regimen that includes leucovorin, 5-fluorouracil and oxaliplatin that can be used in the treatment of ampullary and pancreatic adenocarcinoma, and esophageal and esophagogastric junction and gastric cancer, and mucinous neoplasms of the ovary.
Carboplatin/Cetuximab/Docetaxel Regimen (NCIT:C150690) A chemoimmunotherapy regimen consisting of carboplatin, docetaxel and cetuximab that can be used for the treatment of head and neck cancer and non-small cell lung cancer (NSCLC). A regimen consisting of carboplatin, docetaxel and cetuximab that can be used for the treatment of head and neck cancer and non-small cell lung cancer (NSCLC).

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Synonyms removed: 2460
Term Removed Synonym
White Oak Pollen IgE Antibody Measurement (NCIT:C147282) C147282
White Oak Pollen IgE Antibody Measurement (NCIT:C147282) White Oak Pollen IgE Antibody
White Oak Pollen IgE Antibody Measurement (NCIT:C147282) White Oak Pollen IgE Antibody
Clinical Stage III Cutaneous Merkel Cell Carcinoma AJCC v8 (NCIT:C136877) Clinical Stage III Merkel Cell Carcinoma AJCC v8
Cutaneous Merkel Cell Carcinoma by AJCC v7 Stage (NCIT:C136869) Merkel Cell Carcinoma by AJCC v7 Stage
Cutaneous Merkel Cell Carcinoma by AJCC v7 Stage (NCIT:C136869) Neuroendocrine Carcinoma of the Skin by AJCC v7 Stage
German Cockroach IgE Antibody RAST Score Measurement (NCIT:C165878) C165878
German Cockroach IgE Antibody RAST Score Measurement (NCIT:C165878) German Cockroach IgE AB RAST Score
German Cockroach IgE Antibody RAST Score Measurement (NCIT:C165878) German Cockroach IgE AB RAST Score
FGFR3 NM_000142.4:c.1948A>G (NCIT:C142087) JKT4 c.1948A>G
Treponema pallidum Antibody Measurement (NCIT:C132388) TPLAB

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Nodes renamed: 403
ID Old Label New Label
NCIT:C136877 Clinical Stage III Merkel Cell Carcinoma AJCC v8 Clinical Stage III Cutaneous Merkel Cell Carcinoma AJCC v8
NCIT:C136869 Merkel Cell Carcinoma by AJCC v7 Stage Cutaneous Merkel Cell Carcinoma by AJCC v7 Stage
NCIT:C180328 Gender Questioning Gender Questioning Identity
NCIT:C168580 Bispecific Antibody AMG 509 Xaluritamig
NCIT:C134264 Hardness Hardness Measurement

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