Skyrim GOG Linux Setup

Setup and configuration for the GOG version of Skyrim on Linux, with MO2 support.

Requirements

Bottles - A Wine-based solution to run Windows applications in a sandbox
GOG Galaxy (optional) - If you're going to use Galaxy, I'd recommend using Bottles' own installer script
Skyrim offline installers (optional, use if you're not using Galaxy)
Mod Organizer 2 v2.4.4 - Version 2.5 won't work¹.
Mod Organizer 2 Skyrim plugin - you want SSE GOG and EGS Support - Mod Organizer 2.4.x

First, install Bottles, and set up a new Bottle. I'd recommend importing the included configuration file, since this is my working setup. You can always tweak it later. At a minimum, you'll need to have the latest dotnet, d3dx11 and vcredist dependencies installed in Dependencies, but your experience may vary.
Now install Skyrim. Either install GOG Galaxy via Bottles' script (recommended) and download Skyrim, or run the offline installer exe in the bottle.
Launch Skyrim and start a new game, to confirm everything works and create your config files.
Now install MO2. In the bottle, run the MO2 exe file from the releases page, and complete setup. Be sure to choose a portable installation.
Once installation is complete, replace the Skyrim plugin in the MO2 plugins folder with the download from NexusMods. This will enable GOG support.

You're now done! Boot up MO2, setup your mods and profiles and play the game. Happy modding!
I haven't successfully got downloads from the Nexus working yet, this may be doable if you use a browser inside the Bottle, but for now you'll need to download mods manually and install them in MO2 from their archives.

This guide is very much a hobby project used to track my own setup, so I can't guarantee any level of support.

That being said, if you have suggestions, improvements or questions, feel free to open an issue at https://github.com/Sephsekla/skyrim-gog-linux/issues.