diff --git a/cli/args/flags.rs b/cli/args/flags.rs
index eb77971748a335..0c299d91c391ae 100644
--- a/cli/args/flags.rs
+++ b/cli/args/flags.rs
@@ -597,6 +597,8 @@ pub struct Flags {
   pub argv: Vec<String>,
   pub subcommand: DenoSubcommand,
 
+  /// Flag
+  pub in_memory_cache: Option<bool>,
   pub frozen_lockfile: Option<bool>,
   pub ca_stores: Option<Vec<String>>,
   pub ca_data: Option<CaData>,
@@ -2821,6 +2823,7 @@ fn run_args(command: Command, top_level: bool) -> Command {
     })
     .arg(env_file_arg())
     .arg(no_code_cache_arg())
+    .arg(in_memory_cache_arg())
 }
 
 fn run_subcommand() -> Command {
@@ -3951,6 +3954,13 @@ fn no_clear_screen_arg() -> Arg {
     .help_heading(FILE_WATCHING_HEADING)
 }
 
+fn in_memory_cache_arg() -> Arg {
+  Arg::new("in_memory_cache")
+    .long("in-memory-cache")
+    .help("Disable all filesystem caches and use in-memory cache only")
+    .action(ArgAction::SetTrue)
+}
+
 fn no_code_cache_arg() -> Arg {
   Arg::new("no-code-cache")
     .long("no-code-cache")
diff --git a/cli/args/mod.rs b/cli/args/mod.rs
index e19025f8b10cb6..8a574a74ed8d68 100644
--- a/cli/args/mod.rs
+++ b/cli/args/mod.rs
@@ -1685,6 +1685,10 @@ impl CliOptions {
     self.flags.code_cache_enabled
   }
 
+  pub fn in_memory_cache(&self) -> bool {
+    self.flags.in_memory_cache.unwrap_or(false)
+  }
+
   pub fn watch_paths(&self) -> Vec<PathBuf> {
     let mut full_paths = Vec::new();
     if let DenoSubcommand::Run(RunFlags {
diff --git a/cli/cache/caches.rs b/cli/cache/caches.rs
index 54371cee48bf1f..c433221b175537 100644
--- a/cli/cache/caches.rs
+++ b/cli/cache/caches.rs
@@ -16,6 +16,7 @@ use super::module_info::MODULE_INFO_CACHE_DB;
 use super::node::NODE_ANALYSIS_CACHE_DB;
 
 pub struct Caches {
+  in_memory: bool,
   dir_provider: Arc<DenoDirProvider>,
   fmt_incremental_cache_db: OnceCell<CacheDB>,
   lint_incremental_cache_db: OnceCell<CacheDB>,
@@ -27,8 +28,9 @@ pub struct Caches {
 }
 
 impl Caches {
-  pub fn new(dir: Arc<DenoDirProvider>) -> Self {
+  pub fn new(dir: Arc<DenoDirProvider>, in_memory: bool) -> Self {
     Self {
+      in_memory,
       dir_provider: dir,
       fmt_incremental_cache_db: Default::default(),
       lint_incremental_cache_db: Default::default(),
@@ -41,13 +43,17 @@ impl Caches {
   }
 
   fn make_db(
+    &self,
     cell: &OnceCell<CacheDB>,
     config: &'static CacheDBConfiguration,
     path: Option<PathBuf>,
   ) -> CacheDB {
     cell
       .get_or_init(|| {
-        if let Some(path) = path {
+        // Return in memory cache if in_memory is true
+        if self.in_memory {
+          CacheDB::in_memory(config, crate::version::DENO_VERSION_INFO.deno)
+        } else if let Some(path) = path {
           CacheDB::from_path(
             config,
             path,
@@ -62,6 +68,7 @@ impl Caches {
 
   pub fn fmt_incremental_cache_db(&self) -> CacheDB {
     Self::make_db(
+      self,
       &self.fmt_incremental_cache_db,
       &INCREMENTAL_CACHE_DB,
       self
@@ -74,6 +81,7 @@ impl Caches {
 
   pub fn lint_incremental_cache_db(&self) -> CacheDB {
     Self::make_db(
+      self,
       &self.lint_incremental_cache_db,
       &INCREMENTAL_CACHE_DB,
       self
@@ -86,6 +94,7 @@ impl Caches {
 
   pub fn dep_analysis_db(&self) -> CacheDB {
     Self::make_db(
+      self,
       &self.dep_analysis_db,
       &MODULE_INFO_CACHE_DB,
       self
@@ -98,6 +107,7 @@ impl Caches {
 
   pub fn fast_check_db(&self) -> CacheDB {
     Self::make_db(
+      self,
       &self.fast_check_db,
       &FAST_CHECK_CACHE_DB,
       self
@@ -110,6 +120,7 @@ impl Caches {
 
   pub fn node_analysis_db(&self) -> CacheDB {
     Self::make_db(
+      self,
       &self.node_analysis_db,
       &NODE_ANALYSIS_CACHE_DB,
       self
@@ -122,6 +133,7 @@ impl Caches {
 
   pub fn type_checking_cache_db(&self) -> CacheDB {
     Self::make_db(
+      self,
       &self.type_checking_cache_db,
       &TYPE_CHECK_CACHE_DB,
       self
@@ -134,6 +146,7 @@ impl Caches {
 
   pub fn code_cache_db(&self) -> CacheDB {
     Self::make_db(
+      self,
       &self.code_cache_db,
       &CODE_CACHE_DB,
       self
diff --git a/cli/factory.rs b/cli/factory.rs
index 4a36c75ba2af12..635821be50fa34 100644
--- a/cli/factory.rs
+++ b/cli/factory.rs
@@ -265,7 +265,10 @@ impl CliFactory {
   pub fn caches(&self) -> Result<&Arc<Caches>, AnyError> {
     self.services.caches.get_or_try_init(|| {
       let cli_options = self.cli_options()?;
-      let caches = Arc::new(Caches::new(self.deno_dir_provider()?.clone()));
+      let caches = Arc::new(Caches::new(
+        self.deno_dir_provider()?.clone(),
+        cli_options.in_memory_cache(),
+      ));
       // Warm up the caches we know we'll likely need based on the CLI mode
       match cli_options.sub_command() {
         DenoSubcommand::Run(_)
diff --git a/cli/standalone/mod.rs b/cli/standalone/mod.rs
index 85610f4c20f1f7..4d7a0ecc4c20ff 100644
--- a/cli/standalone/mod.rs
+++ b/cli/standalone/mod.rs
@@ -632,7 +632,7 @@ pub async fn run(data: StandaloneData) -> Result<i32, AnyError> {
       unstable_detect_cjs: metadata.unstable_config.detect_cjs,
     },
   ));
-  let cache_db = Caches::new(deno_dir_provider.clone());
+  let cache_db = Caches::new(deno_dir_provider.clone(), false);
   let node_analysis_cache = NodeAnalysisCache::new(cache_db.node_analysis_db());
   let cli_node_resolver = Arc::new(CliNodeResolver::new(
     cjs_tracker.clone(),