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InterPro:IPR045296|PANTHER:PTN000471017 is not part of respiratory chain but regulates #5557

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hattrill opened this issue Nov 29, 2024 · 0 comments

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@hattrill
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InterPro:IPR045296
PANTHER:PTN000471017 ; GROWTH HORMONE-INDUCIBLE SOLUBLE PROTEIN-RELATED (PTHR21024)

This corresponds to ETF Regulatory Factor 1 (ETFRF1). Its interaction with the electron transferring flavoprotein (EFT) complex results in the removal of the flavin from the ETFA subunit and stops the transfer of electrons into the respiratory chain. PMID:27499296, PMID:36266680

I think that 'respiratory electron transport chain' is incorrect. 'negative regulation of oxidative phosphorylation' is a more accurate term as ETF is thought of as part of oxidative phosphorylation.

(For PAINT, I have just added this to FBgn0040985, replacing 'negative regulation of cellular respiration'....might be a while coming, but could be used for propagation when it does)

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