Issue 29329

[pgaudet]

No description provided.

[github-actions]

Here's a diff of how these changes impact the classified ontology:

Ontology comparison

Left

• Ontology IRI: http://purl.obolibrary.org/obo/go.owl
• Version IRI: http://purl.obolibrary.org/obo/go/releases/2024-11-29/go.owl
• Loaded from: file:/__w/go-ontology/go-ontology/src/ontology/../../reasoned-master.owl/reasoned.owl

Right

• Ontology IRI: http://purl.obolibrary.org/obo/go.owl
• Version IRI: http://purl.obolibrary.org/obo/go/releases/2024-11-29/go.owl
• Loaded from: file:/__w/go-ontology/go-ontology/src/ontology/../../reasoned-pr.owl/reasoned.owl

Ontology imports

Ontology annotations

17-beta-ketosteroid reductase (NADPH) activity http://purl.obolibrary.org/obo/GO_0072555

Removed

• 17-beta-ketosteroid reductase (NADPH) activity definition "Catalysis of the reaction: a 17-beta-ketosteroid + NADPH + H+ = a 17-beta-hydroxysteroid + NADP+."

  • database_cross_reference "PMID:17074428"

  • database_cross_reference "GOC:kad"

• 17-beta-ketosteroid reductase (NADPH) activity label "17-beta-ketosteroid reductase (NADPH) activity"

• 17-beta-ketosteroid reductase (NADPH) activity SubClassOf steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

Added

• 17-beta-ketosteroid reductase (NADPH) activity term tracker item "https://github.com/geneontology/go-ontology/issues/29329"^^[anyURI](http://www.w3.org/2001/XMLSchema#anyURI)

• 17-beta-ketosteroid reductase (NADPH) activity consider "GO:0072582"

• 17-beta-ketosteroid reductase (NADPH) activity comment "This term was obsoleted because it was an unnecessary grouoing term."

• 17-beta-ketosteroid reductase (NADPH) activity definition "OBSOLETE. Catalysis of the reaction: a 17-beta-ketosteroid + NADPH + H+ = a 17-beta-hydroxysteroid + NADP+."

  • database_cross_reference "PMID:17074428"

  • database_cross_reference "GOC:kad"

• 17-beta-ketosteroid reductase (NADPH) activity deprecated true

• 17-beta-ketosteroid reductase (NADPH) activity label "obsolete 17-beta-ketosteroid reductase (NADPH) activity"

5-beta-cholestane-3-alpha,7-alpha-diol 12-alpha-hydroxylase activity http://purl.obolibrary.org/obo/GO_0033779

Added

• 5-beta-cholestane-3-alpha,7-alpha-diol 12-alpha-hydroxylase activity term tracker item "https://github.com/geneontology/go-ontology/issues/29331"^^[anyURI](http://www.w3.org/2001/XMLSchema#anyURI)

7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase activity http://purl.obolibrary.org/obo/GO_0033778

Removed

• 7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase activity has_related_synonym "7alpha-hydroxy-4-cholesten-3-one 12alpha-monooxygenase activity"
  • database_cross_reference "EC:1.14.14.139"

Added

• 7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase activity term tracker item "https://github.com/geneontology/go-ontology/issues/29331"^^[anyURI](http://www.w3.org/2001/XMLSchema#anyURI)

sterol 12-alpha-hydroxylase activity http://purl.obolibrary.org/obo/GO_0008397

Removed

• sterol 12-alpha-hydroxylase activity definition "Catalysis of the reaction: a steroid + donor-H2 + O2 = 12-alpha-hydroxysteroid + H2O."

  • database_cross_reference "GOC:mah"

• sterol 12-alpha-hydroxylase activity database_cross_reference "EC:1.14.14.139"

Added

• sterol 12-alpha-hydroxylase activity definition "Catalysis of the reaction: a steroid + reduced [NADPH--hemoprotein reductase] + O2 = a 12-alpha-hydroxysteroid + oxidized [NADPH--hemoprotein reductase]- H2O +H+."

  • database_cross_reference "EC:1.14.14.139"

• sterol 12-alpha-hydroxylase activity database_cross_reference "EC:1.14.14.139"

  • source "skos:exactMatch"

vitamin D 25-hydroxylase activity http://purl.obolibrary.org/obo/GO_0070643

Removed

• vitamin D 25-hydroxylase activity label "vitamin D 25-hydroxylase activity"

• vitamin D 25-hydroxylase activity definition "Catalysis of the hydroxylation of C-25 of any form of vitamin D."

  • database_cross_reference "GOC:mah"

  • database_cross_reference "GOC:BHF"

• vitamin D 25-hydroxylase activity SubClassOf steroid hydroxylase activity

Added

• vitamin D 25-hydroxylase activity comment "This term was obsoleted because it was an unnecessary grouping term."

• vitamin D 25-hydroxylase activity deprecated true

• vitamin D 25-hydroxylase activity term tracker item "https://github.com/geneontology/go-ontology/issues/29330"^^[anyURI](http://www.w3.org/2001/XMLSchema#anyURI)

• vitamin D 25-hydroxylase activity consider "GO:0030343"

• vitamin D 25-hydroxylase activity label "obsolete vitamin D 25-hydroxylase activity"

• vitamin D 25-hydroxylase activity definition "OBSOLETE. Catalysis of the hydroxylation of C-25 of any form of vitamin D."

  • database_cross_reference "GOC:mah"

  • database_cross_reference "GOC:BHF"

vitamin D3 25-hydroxylase activity http://purl.obolibrary.org/obo/GO_0030343

Removed

• vitamin D3 25-hydroxylase activity database_cross_reference "RHEA:32903"

• vitamin D3 25-hydroxylase activity definition "Catalysis of the reaction: vitamin D3 + NADPH + H+ + O2 = calcidiol + NADP+ + H2O."

  • database_cross_reference "ISBN:0471331309"

  • database_cross_reference "MetaCyc:RXN-9829"

• vitamin D3 25-hydroxylase activity SubClassOf vitamin D 25-hydroxylase activity

Added

• vitamin D3 25-hydroxylase activity database_cross_reference "RHEA:32903"

  • source "skos:exactMatch"

• vitamin D3 25-hydroxylase activity database_cross_reference "EC:1.14.14.24"

  • source "skos:exactMatch"

• vitamin D3 25-hydroxylase activity definition "Catalysis of the reaction: calciol (vitamin D3) + reduced [NADPH--hemoprotein reductase] + O2 = calcidiol + oxidized [NADPH--hemoprotein reductase]+ + H2O +H2."

  • database_cross_reference "RHEA:32903"

• vitamin D3 25-hydroxylase activity SubClassOf steroid hydroxylase activity