Numbers of annotations per gene

[diatomsRcool]

Hello. I am interested in looking at the number of annotations per gene. Specifically, I would like a list of genes in GO with no or very few annotations. Any suggestions on how I might get started on this? Thanks!

[suzialeksander]

Hi @diatomsRcool, were you interested in a specific organism?

[diatomsRcool]

human

[suzialeksander]

Hi @diatomsRcool,

Did you try using the files at https://ftp.ebi.ac.uk/pub/databases/GO/goa/UNIPROT/ ? You should be able to filter by taxon, then sort by accession and compare to the reference proteome. If you tried this and goa_uniprot_all.gaf wasn't what you were looking for, please let me know.

[llrs]

I know this is an old question, but it might help future users.

I have done this via R using the annotation provided in Bioconductor by the org.Hs.eg.db annotation package.
The examples are in the vignette of a package that can read *.obo files (if it helps for other users).