diff --git a/setup.py b/setup.py
index dbcdd06..6d92eb4 100644
--- a/setup.py
+++ b/setup.py
@@ -30,7 +30,7 @@
     'numpy',
     'pandas >= 0.18.1',
     'pretty_midi >= 0.2.6',
-    'protobuf >= 3.6.1',
+    'protobuf >= 4.21.2',
     'pydub',
     'scipy >= 0.18.1',
 ]